Colts face their first road test at Tennessee after a 2-0 start that leaned on early offense and clutch special teams. Indy sits as a -3.5 favorite with a -166 money line and a 42.5 over/under, signaling a tight, grind-it-out divisional affair. The win over Denver featured a bold start and late heroics from Shrader and Lutz, while the Titans’ rookie Cam Ward has shown upside but finishing drives remains a work in progress.

Fantasy angles hinge on Ward’s early impact and the Colts’ improving weaponry. If Ward can sustain drives, Tennessee’s ceiling rises; if not, Indy’s defense and kicking game could tilt the balance. This matchup sets up as a pivotal early-season test that could define who controls the division and which players emerge as weekly fantasy starters or sit-downs.

Los Angeles rode a second-half surge to a commanding 33-19 win, flipping the script on Tennessee after a tight first half. Stafford and the Rams’ aerial attack clicked late, with Adams and Nacua thriving as high-volume options and Williams providing steady ground threat. The performance boosts fantasy angles: a revitalized pass game around a veteran QB and a rookie receiver corps with ceiling looks.

Adams delivered season-highlight numbers, Nacua maintained his target-heavy role, and Stafford pressed the tempo as L.A. leaned on a dangerous passing attack. Williams’ workload remained under mild scrutiny despite efficient production, while the Titans’ defense and rookie Cam Ward offered early intrigue but couldn’t keep pace when the Rams flipped the switch in the second half.